4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

Base Information

Chemical Name:4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole
CAS No.:263407-03-0
Molecular Formula:C₂₃H₃₁NO₄SSi
Molecular Weight:445.655
Hs Code.:

Synonyms:4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

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Chemical Property of 4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

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Technology Process of 4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

There total 4 articles about 4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 263407-04-1
(5-benzenesulfonylmethyl-4,5-dihydro-isoxazol-3-yl)-phenyl-methanol

: 263407-03-0
4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/S0040-4020(99)01063-7

Reference yield:

: 16212-05-8
(allylsulfonyl)benzene

: 263407-03-0
4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N; phenyl isocyanate / diethyl ether / 72 h

2: 72 percent / citric acid / methanol / 1 h / 20 °C

3: 92 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; phenyl isocyanate; triethylamine; citric acid; In methanol; diethyl ether; dichloromethane; 1: Cycloaddition / 2: desilylation / 3: silylation;
DOI:10.1016/S0040-4020(99)01063-7

Reference yield:

: 155112-29-1
1-Nitro-2-phenyl-2-<(trimethylsilyl)oxy>-1-ethane

: 263407-03-0
4,5-dihydro-5-{[(phenyl)sulfonyl]methyl}-3-{phenyl[(tert-butyldimethylsilyl)oxy]methyl}isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N; phenyl isocyanate / diethyl ether / 72 h

2: 72 percent / citric acid / methanol / 1 h / 20 °C

3: 92 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; phenyl isocyanate; triethylamine; citric acid; In methanol; diethyl ether; dichloromethane; 1: Cycloaddition / 2: desilylation / 3: silylation;
DOI:10.1016/S0040-4020(99)01063-7