3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane

Base Information

• Chemical Name: 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane
• CAS No.: 130220-13-2
• Molecular Formula: C₂₉H₃₈O₄S₃Si
• Molecular Weight: 574.902
• Mol file: 130220-13-2.mol

Synonyms:3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane

Chemical Property of 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane

There total 7 articles about 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

potassium thiotosylate (28519-50-8) + 7-iodo-3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)heptane (130220-10-9) → 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane (130220-13-2)

Guidance literature:

In water; acetone; for 20h; Ambient temperature;

Reference yield: 75.0%

potassium thiotosylate (28519-50-8) + 7-iodo-3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)heptane (130220-10-9) → 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane (130220-13-2) + 5-(trimethylsilyl)-7-phenyl-5-(phenylsulfonyl)heptanyl p-toluenesulfonyl disulfide (130220-16-5)

Guidance literature:

In water; acetone; for 20h; Ambient temperature;

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane (130220-13-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 1 h / 25 °C

2: 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 25 °C

3: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to 25 deg C

4: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) from -78 deg C to RT, 4 h

5: 88 percent / acetone; H₂O / 20 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; acetone;

upstream raw materials:

potassium thiotosylate

7-iodo-3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)heptane

((3-phenylpropyl)sulfonyl)benzene

1-Bromo-3-phenylpropane

Downstream raw materials:

2-phenethyl-2-(phenylsulfonyl)-1-thiacyclohexane S,S-dioxide

2-(cyclopent-1-enyl)ethylbenzene