(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Base Information

Chemical Name:(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol
CAS No.:943141-62-6
Molecular Formula:C₃₂H₃₃ClO₂
Molecular Weight:485.066
Hs Code.:

Synonyms:(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Suppliers and Price of (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

There total 11 articles about (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 524937-26-6
ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamate

: 943141-62-6
(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 3h;
DOI:10.1021/jm0613323

Reference yield:

: 103909-79-1
ethyl (E)-3-chloro-4-hydroxycinnamate

: 943141-62-6
(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / pyridine / CH₂Cl₂ / 20 °C

2: 91 percent / LiCl; aq. Na₂CO₃ / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating

3: 91 percent / DIBAL / CH₂Cl₂; hexane / 3 h / -78 °C

With pyridine; diisobutylaluminium hydride; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; 2: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323

Reference yield:

: 524937-24-4
(E)-ethyl 3-(3-chloro-4-(trifluoromethylsulphonyloxy)phenyl)acrylate

: 943141-62-6
(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LiCl; aq. Na₂CO₃ / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating

2: 91 percent / DIBAL / CH₂Cl₂; hexane / 3 h / -78 °C

With diisobutylaluminium hydride; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; 1: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323