methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate

Base Information

• Chemical Name: methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate
• CAS No.: 37510-36-4
• Molecular Formula: C₁₁H₁₂OS₂
• Molecular Weight: 224.348
• Mol file: 37510-36-4.mol

Synonyms:methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate

Chemical Property of methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate

There total 2 articles about methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S,S)-dimethyl trithiocarbonate (2314-48-9) + para-methylacetophenone (122-00-9) → methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate (37510-36-4)

Guidance literature:

para-methylacetophenone; With sodium hydride; In hexane; N,N-dimethyl-formamide; mineral oil; at 20 ℃;

(S,S)-dimethyl trithiocarbonate; In hexane; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

With hydrogenchloride; In hexane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.tet.2010.11.055

Reference yield: 30.0%

carbon disulfide (75-15-0,12122-00-8) + para-methylacetophenone (122-00-9) + methyl iodide (74-88-4) → methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate (37510-36-4)

Guidance literature:

carbon disulfide; para-methylacetophenone; With potassium tert-butylate; In diethyl ether; at 0 ℃; for 1.5h; Inert atmosphere;

methyl iodide; In diethyl ether; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2014.07.023

Reference yield: 94.0%

methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate (37510-36-4) + 4-methyl-benzaldehyde (104-87-0) + dimedone (126-81-8) + Cysteamine (60-23-1) → 8,8-dimethyl-4-(4-methylbenzoyl)-5-p-tolyl-1,2,5,7,9-pentahydrothiazolo[3,2-a]quinolin-6-one

Guidance literature:

With 1-propylamine-3-methylimidazolium tungstophosphoric acid supported on Fe₃O₄/SiO₂/salen/Mn nanoparticle; In neat (no solvent); at 20 ℃; Green chemistry;

DOI:10.1039/c4ra16726k

upstream raw materials:

carbon disulfide

para-methylacetophenone

methyl iodide

(S,S)-dimethyl trithiocarbonate

Downstream raw materials:

3-(4-methylbenzoyl)-2H-chromene-2-thione

3-(4-methylbenzoyl)-2H-chromen-2-one

3-(4-methylbenzoyl)-8-methoxy-2H-chromene-2-thione

3-(4-methylbenzoyl)-6-nitro-2H-chromene-2-thione