ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

Base Information

Chemical Name:ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate
CAS No.:1251930-02-5
Molecular Formula:C₂₁H₁₇FN₄O₄
Molecular Weight:408.389
Hs Code.:

Synonyms:ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

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Chemical Property of ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

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Technology Process of ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

There total 5 articles about ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.9%

: 1251930-01-4
ethyl [3-(bromomethyl)-2-fluorophenyl]carbamate

: 72159-22-9
2-(1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione

: 1251930-02-5
ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

: 1251930-27-4
ethyl (3-{[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

Guidance literature:: 2-(1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.333333h; Inert atmosphere;

ethyl [3-(bromomethyl)-2-fluorophenyl]carbamate; In acetonitrile; at 20 - 70 ℃;

Reference yield:

: 914223-43-1
3-amino-2-fluoro benzoic acid

: 1251930-02-5
ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

: 1251930-27-4
ethyl (3-{[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: sodium carbonate / water / 1.5 h / 0 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4.2: 20 - 70 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium carbonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 85-44-9
phthalic anhydride

: 1251930-02-5
ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

: 1251930-27-4
ethyl (3-{[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 17 h / Reflux

2.1: potassium carbonate / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 - 70 °C

With potassium carbonate; In 1,4-dioxane; acetonitrile;