72159-22-9

Basic information

• Product Name: 2-(1H-pyrazol-3-yl)isoindoline-1,3-dione
• Synonyms: 2-(1H-pyrazol-3-yl)isoindoline-1,3-dione
• CAS NO: 72159-22-9
• Molecular Weight: 213.195
• Mol File: 72159-22-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(1H-pyrazol-3-yl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-pyrazol-3-yl)isoindoline-1,3-dione(72159-22-9)
• EPA Substance Registry System: 2-(1H-pyrazol-3-yl)isoindoline-1,3-dione(72159-22-9)

Safety Data

• Hazardous Substances Data: 72159-22-9(Hazardous Substances Data)

Usage

Chemical structure

The compound consists of a pyrazole ring and an isoindoline-1,3-dione moiety.

Biological activity

The pyrazole ring can impart biological activity to the molecule, making it potentially useful in drug development.

Structural and electronic properties

The isoindoline-1,3-dione group can contribute to the compound's structural and electronic properties, making it a versatile building block for the synthesis of new materials.

Potential applications

2-(1H-pyrazol-3-yl)isoindoline-1,3-dione has potential applications in the field of pharmaceuticals and materials science.

Versatility

The compound's unique structure and properties make it a promising candidate for various chemical and biological applications, warranting further investigation for its potential uses.

Upstream product

• 85-44-9 phthalic anhydride 
• 1820-80-0 3-aminopyrazole 

Downstream Products

• 72159-23-0 N-(1-benzyl-1H-pyrazol-3-yl)-phthalimide 
• 1033780-34-5 1-pyridine-3-ylmethyl-1H-pyrazole-3-ylamine 
• 1251930-02-5 ethyl (3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate 
• 1251930-27-4 ethyl (3-{[5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2-fluorophenyl)carbamate 
• 1251930-03-6 N-(3-{[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-1-yl]methyl}-2,4-difluorophenyl)acetamide 
• 1251929-63-1 2-{1-[(2-fluoro-3-methylphenyl)methyl]-1H-pyrazol-3-yl}-1H-isoindole-1,3(2H)-dione 
• 1251929-62-0 2-{1-[(3-chloro-2-fluorophenyl)methyl]-1H-pyrazol-3-yl}-1H-isoindole-1,3(2H)-dione 
• 1253188-43-0 2-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione 
• 1253188-39-4 2-(1-{[4-chloro-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione 
• 1253188-41-8 2-(1-{[2-(phenyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione 
• 1253188-31-6 2-[1-({2-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicyclic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof: (I), Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, -CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

CARBOXAMIDE-HETEROARYL DERIVATIVES FOR THE TREATMENT OF DIABETES

Novel heterocyclic compounds of the formula (I) wherein D is formula (A) or formula (B) wherein R1, R2, E', E'', E''', Y'', Y'', G', G'', G''' and G''' have the meaning of claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.