(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

Base Information

Chemical Name:(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester
CAS No.:121329-97-3
Molecular Formula:C₁₇H₃₁O₅PSi
Molecular Weight:374.489
Hs Code.:

Synonyms:(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

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Chemical Property of (S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

Chemical Property:

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Technology Process of (S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

There total 4 articles about (S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 121329-94-0
(S)-(+)-<2-(Benzyloxy)-1-hydroxyethyl>phosphonsaeure-dimethylester

: 121329-97-3
(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 121329-97-3
(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / DBU / CH₂Cl₂ / 1 h

2: 18 percent / p-toluenesulfonic acid hydrate, molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h

3: 89 percent / p-toluenesulfonic acid hydrate / CH₂Cl₂; methanol / 1 h / Ambient temperature

4: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; 4 A molecular sieve; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 121421-26-9
<2-(Benzyloxy)-1-hydroxyethyl>phosphonsaeure-dimethylester

: 121329-97-3
(S)-(+)-<2-(Benzyloxy)-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 18 percent / p-toluenesulfonic acid hydrate, molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h

2: 89 percent / p-toluenesulfonic acid hydrate / CH₂Cl₂; methanol / 1 h / Ambient temperature

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; 4 A molecular sieve; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;