6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

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Chemical Name:6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid
CAS No.:868616-76-6
Molecular Formula:C₁₇H₁₄FNO₄
Molecular Weight:315.301
Hs Code.:

Synonyms:6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

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Chemical Property of 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

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Technology Process of 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

There total 5 articles about 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1369355-64-5
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

: 868616-76-6
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

Guidance literature:: 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester; With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm401040b

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 868616-76-6
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 90 °C

2: sodium hydroxide / 24 h / 25 °C

3: sodium ethanolate / tetrahydrofuran / 25 °C

4: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / 25 °C

With sodium ethanolate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.2174/092986711796504619

Reference yield:

: 63880-57-9
1-[(2-fluorophenyl)methyl]pyrrole-2-carboxaldehyde

: 868616-76-6
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 24 h / 25 °C

2: sodium ethanolate / tetrahydrofuran / 25 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 1.5 h / 25 °C

With sodium ethanolate; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.2174/092986711796504619