6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

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Chemical Name:6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester
CAS No.:1369355-64-5
Molecular Formula:C₁₉H₁₈FNO₄
Molecular Weight:343.355
Hs Code.:

Synonyms:6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

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Chemical Property of 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

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Technology Process of 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

There total 4 articles about 6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₁₅H₁₄FNO

: 95-92-1
oxalic acid diethyl ester

: 1369355-64-5
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

Guidance literature:: With sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm401040b

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1369355-64-5
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 90 °C

2: sodium hydroxide / 24 h / 25 °C

3: sodium ethanolate / tetrahydrofuran / 25 °C

With sodium ethanolate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.2174/092986711796504619

Reference yield:

: 63880-57-9
1-[(2-fluorophenyl)methyl]pyrrole-2-carboxaldehyde

: 1369355-64-5
6-[1-(2-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 24 h / 25 °C

2: sodium ethanolate / tetrahydrofuran / 25 °C

With sodium ethanolate; sodium hydroxide; In tetrahydrofuran;
DOI:10.2174/092986711796504619