3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

Base Information

Chemical Name:3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one
CAS No.:321656-99-9
Molecular Formula:C₁₉H₁₃BrCl₂IN₃O
Molecular Weight:577.046
Hs Code.:

3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1<i>H</i>-imidazo[1,2-<i>a</i>]imidazol-2-one

Synonyms:3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

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Chemical Property of 3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

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Technology Process of 3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

There total 6 articles about 3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 321724-15-6
3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5,6-diiodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one

: 321656-99-9
3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

Guidance literature:: With cyclopentylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -30 ℃; for 1.5h;
DOI:10.1021/jm049657b

Reference yield:

: 6590-93-8
3,5-dichlorophenylisothiocyanate

: 321656-99-9
3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / dioxane / 90 °C

2: 1.96 g / toluene / 130 - 140 °C

3: trifluoroacetic acid / CH₂Cl₂ / 90 °C

4: 60 percent / N-iodosuccinimide; pyridinium p-toluenesulfonate / CH₂Cl₂ / 0 °C

5: 60 percent / cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / -30 °C

With N-iodo-succinimide; pyridinium p-toluenesulfonate; trifluoroacetic acid; cyclopentylmagnesium bromide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm049657b

Reference yield:

: 213202-98-3
ethyl 2-amino-2-(4-bromobenzyl)-propanoate

: 321656-99-9
3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-6-iodo-3-methyl-1H-imidazo[1,2-a]imidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / dioxane / 90 °C

2: 1.96 g / toluene / 130 - 140 °C

3: trifluoroacetic acid / CH₂Cl₂ / 90 °C

4: 60 percent / N-iodosuccinimide; pyridinium p-toluenesulfonate / CH₂Cl₂ / 0 °C

5: 60 percent / cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / -30 °C

With N-iodo-succinimide; pyridinium p-toluenesulfonate; trifluoroacetic acid; cyclopentylmagnesium bromide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm049657b