(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

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Chemical Name:(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol
CAS No.:158663-87-7
Molecular Formula:C₂₇H₂₅NO₄
Molecular Weight:427.5
Hs Code.:

Synonyms:(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

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Chemical Property of (R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

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Technology Process of (R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

There total 8 articles about (R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 158663-82-2
1-Benzofuran-2-yl-2-[(2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanone

: 158663-87-7
(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

: (R)-1-Benzofuran-2-yl-2-[((R)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

Guidance literature:: With R-Alpine-Hydride; In tetrahydrofuran; at -98 - 23 ℃; for 18h; Yields of byproduct given;
DOI:10.1016/S0040-4039(00)73275-8

Reference yield:

: 23489-36-3
1-(benzofuran-2-yl)-2-bromoethan-1-one

: 158663-87-7
(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / N,N-diisopropylethalamine / tetrahydrofuran / 16 h / 5 - 23 °C

2: (R)-alpine-hydride / tetrahydrofuran / 18 h / -98 - 0 °C / further reagents and solvents

With R-Alpine-Hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jo981341m

Reference yield:

: 1646-26-0
1-(benzo[b]furan-2-yl)ethanone

: 158663-87-7
(R)-1-Benzofuran-2-yl-2-[((S)-2-benzofuran-2-yl-2-hydroxy-ethyl)-benzyl-amino]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 2-pyrrolidinone hydrotribromide, 2-pyrrolidinone / 3 h / Heating

2: 63 percent / N,N-diisopropylethalamine / tetrahydrofuran / 16 h / 5 - 23 °C

3: (R)-alpine-hydride / tetrahydrofuran / 18 h / -98 - 0 °C / further reagents and solvents

With 2-pyrrolidinon; pyrrolidone hydrotribromide; R-Alpine-Hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jo981341m