5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

Base Information

Chemical Name:5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride
CAS No.:204512-53-8
Molecular Formula:C₁₈H₁₂ClFO₃S₂
Molecular Weight:394.875
Hs Code.:

Synonyms:5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

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Chemical Property of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

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Technology Process of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

There total 4 articles about 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140402-91-1
5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylic acid

: 204512-53-8
5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

Guidance literature:: With phosphorus pentachloride; In tetrahydrofuran; toluene; for 1h; Ambient temperature;
DOI:10.1248/cpb.46.279

Reference yield:

: 36187-57-2
1-(4-fluorophenyl)-2-(4-(methylthio)phenyl)ethanone

: 204512-53-8
5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) POCl₃ / 1.) 1,2-dichloroethane, RT, 30 min, 2.) 1,2-dichloroethane, reflux, 10 h

2: 60 percent / Et₃N, pyridine / 1.) 70 deg C, 1 h, 2.) reflux, 3 h

3: 68 percent / 30percent aq. H₂O₂, AcOH / 3 h / 70 °C

4: 8.1 g / PCl₅ / toluene; tetrahydrofuran / 1 h / Ambient temperature

With pyridine; phosphorus pentachloride; dihydrogen peroxide; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene;
DOI:10.1248/cpb.46.279

Reference yield:

: 204512-52-7
5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]thiophene-2-carboxylic acid

: 204512-53-8
5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 30percent aq. H₂O₂, AcOH / 3 h / 70 °C

2: 8.1 g / PCl₅ / toluene; tetrahydrofuran / 1 h / Ambient temperature

With phosphorus pentachloride; dihydrogen peroxide; acetic acid; In tetrahydrofuran; toluene;
DOI:10.1248/cpb.46.279