1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

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Chemical Name:1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine
CAS No.:719302-91-7
Molecular Formula:C₃₁H₃₈F₃N₃O₇S₃Si
Molecular Weight:745.937
Hs Code.:

1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

Synonyms:1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

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Chemical Property of 1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

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Technology Process of 1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

There total 2 articles about 1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 129678-64-4
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-β-D-arabino-pentofuranosyl>thymine

: 719302-91-7
1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

Guidance literature:: With pyridine; In dichloromethane; at 0 - 5 ℃;
DOI:10.1081/NCN-120028337

Reference yield:

: 1-(2,3-epoxy-5-O-tert-butyldiphenylsilyl-β-D-lyxo-pentofuranosyl)thymine

: 719302-91-7
1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; hexamethylphosphoramide / tetrahydrofuran; pentane / 1 h / -78 °C

1.2: 69 percent / hexamethylphosphoramide / tetrahydrofuran; pentane / 1.5 h

2.1: 70 percent / pyridine / CH₂Cl₂ / 0 - 5 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1081/NCN-120028337

Reference yield: 73.0%

: 719302-91-7
1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine

: 719303-07-8
1-[2,3-dideoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-fluoro-β-D-ribo-pentofuranosyl]thymine

: 719302-92-8
1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-fluoro-β-D-ribo-pentofuranosyl]thymine

Guidance literature:: 1-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-2-O-(trifluoromethanesulfonyl)-β-D-arabino-pentofuranosyl]thymine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 5 ℃;

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran;
DOI:10.1081/NCN-120028337