C₅₃H₆₃N₅O₇

Base Information

• Chemical Name: C₅₃H₆₃N₅O₇
• CAS No.: 1043910-82-2
• Molecular Formula: C₅₃H₆₃N₅O₇
• Molecular Weight: 882.113
• Mol file: 1043910-82-2.mol

Synonyms:C₅₃H₆₃N₅O₇

Chemical Property of C₅₃H₆₃N₅O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₆₃N₅O₇

There total 5 articles about C₅₃H₆₃N₅O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-demethoxycarbonyl-3-(4’-toluoylamino)methylvindoline (1043910-12-8) + 3-demethoxycarbonyl-3-hydroxylmethyl-3b,22-epoxide-4-deacetylvindoline (2468-21-5,20395-98-6,67110-66-1,113158-99-9) → C53H63N5O7 (1043910-82-2)

Guidance literature:

3-demethoxycarbonyl-3-(4’-toluoylamino)methylvindoline; 3-demethoxycarbonyl-3-hydroxylmethyl-3b,22-epoxide-4-deacetylvindoline; With iron(III) chloride; sodium hydrogen sulfate; In 2,2,2-trifluoroethanol; water; at 25 ℃; for 8h; Inert atmosphere; Darkness;

With ammonium hydroxide; sodium tetrahydroborate; In 2,2,2-trifluoroethanol; water; at 0 ℃; for 0.5h; Inert atmosphere; Darkness;

DOI:10.1016/j.bmcl.2012.10.024

Reference yield:

3-demethoxycarbonyl-3-aminomethyl-4-O-deacetylvindoline (943304-62-9) → C53H63N5O7 (1043910-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate / tetrahydrofuran; water / 1 h / 20 °C

2.1: pyridine / 8 h / 20 °C

3.1: iron(III) chloride; sodium hydrogen sulfate / water; 2,2,2-trifluoroethanol / 8 h / 25 °C / Inert atmosphere; Darkness

3.2: 0.5 h / 0 °C / Inert atmosphere; Darkness

With pyridine; iron(III) chloride; sodium hydrogen sulfate; sodium acetate; In tetrahydrofuran; 2,2,2-trifluoroethanol; water;

DOI:10.1016/j.bmcl.2012.10.024

Reference yield:

C30H37N3O4 → C53H63N5O7 (1043910-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 8 h / 20 °C

2.1: iron(III) chloride; sodium hydrogen sulfate / water; 2,2,2-trifluoroethanol / 8 h / 25 °C / Inert atmosphere; Darkness

2.2: 0.5 h / 0 °C / Inert atmosphere; Darkness

With pyridine; iron(III) chloride; sodium hydrogen sulfate; In 2,2,2-trifluoroethanol; water;

DOI:10.1016/j.bmcl.2012.10.024

upstream raw materials:

3-demethoxycarbonyl-3-(4’-toluoylamino)methylvindoline

3-demethoxycarbonyl-3-hydroxylmethyl-3b,22-epoxide-4-deacetylvindoline

3-demethoxycarbonyl-3-aminomethyl-4-O-deacetylvindoline

4-methyl-benzoyl chloride

Downstream raw materials:

3-demethoxycarbonyl-3-(4'-tolylamino)methylvinorelbine