C₃₉H₅₂N₂O₉

Base Information

• Chemical Name: C₃₉H₅₂N₂O₉
• CAS No.: 1350818-22-2
• Molecular Formula: C₃₉H₅₂N₂O₉
• Molecular Weight: 692.85
• Mol file: 1350818-22-2.mol

Synonyms:C₃₉H₅₂N₂O₉

Chemical Property of C₃₉H₅₂N₂O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₅₂N₂O₉

There total 13 articles about C₃₉H₅₂N₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol (932739-33-8) + (S)-2-{3-[(R)-2-Acryloylamino-3-(4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid (1026015-46-2) → C39H52N2O9 (1350818-22-2)

Guidance literature:

(S)-2-{3-[(R)-2-Acryloylamino-3-(4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid; With 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

(2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol; With dmap; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2011.09.134

Reference yield:

C25H34O7S (1350818-15-3) → C39H52N2O9 (1350818-22-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: sodium iodide / acetone / 24 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

3.1: ozone / dichloromethane / 0.25 h / -78 °C

4.1: diethyl ether / diethyl ether; dichloromethane / 0.75 h / -78 °C

5.1: methanol; toluene-4-sulfonic acid / 6 h / Reflux

6.1: pyridinium p-toluenesulfonate / 3 h / 20 °C

7.1: methanol; potassium carbonate / 2 h / 20 °C

8.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h

9.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 1 h / 20 °C

10.1: potassium tert-butylate / tetrahydrofuran / 0 °C

10.2: 4 h / 0 - 20 °C

11.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C

11.2: 18 h / 20 °C

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethyl ether; [bis(acetoxy)iodo]benzene; 2,4,6-trichlorobenzoyl chloride; 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; ozone; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; 10.1: Wittig reaction / 10.2: Wittig reaction / 11.1: Yamaguchi esterification / 11.2: Yamaguchi esterification;

DOI:10.1016/j.tetlet.2011.09.134

Reference yield:

C18H27IO4 (1350818-16-4) → C39H52N2O9 (1350818-22-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

2.1: ozone / dichloromethane / 0.25 h / -78 °C

3.1: diethyl ether / diethyl ether; dichloromethane / 0.75 h / -78 °C

4.1: methanol; toluene-4-sulfonic acid / 6 h / Reflux

5.1: pyridinium p-toluenesulfonate / 3 h / 20 °C

6.1: methanol; potassium carbonate / 2 h / 20 °C

7.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h

8.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 1 h / 20 °C

9.1: potassium tert-butylate / tetrahydrofuran / 0 °C

9.2: 4 h / 0 - 20 °C

10.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C

10.2: 18 h / 20 °C

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethyl ether; [bis(acetoxy)iodo]benzene; 2,4,6-trichlorobenzoyl chloride; 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; ozone; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 9.1: Wittig reaction / 9.2: Wittig reaction / 10.1: Yamaguchi esterification / 10.2: Yamaguchi esterification;

DOI:10.1016/j.tetlet.2011.09.134

upstream raw materials:

(2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol

(S)-2-{3-[(R)-2-Acryloylamino-3-(4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

C₂₅H₃₄O₇S

C₁₈H₂₇IO₄

Downstream raw materials:

C₃₇H₄₈N₂O₉

C₃₄H₄₄N₂O₉

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