N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine

Base Information

• Chemical Name: N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine
• CAS No.: 683243-08-5
• Molecular Formula: C₃₂H₃₅F₉N₆OSi
• Molecular Weight: 718.741
• Mol file: 683243-08-5.mol

Synonyms:N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine

Chemical Property of N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine

There total 8 articles about N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-bromo-3-trifluoromethylphenyl)acetamide (41513-05-7) → N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine (683243-08-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 7.2 g / H₂SO₄; HNO₃ / H₂O / 3 h / 20 °C

2: 88 percent / aq. NaOH / methanol / 2 h / 90 °C

3: 93 percent / SnCl₂*2H₂O / ethyl acetate; ethanol / 1 h / 70 °C

4: 97 percent / tetrahydrofuran / 16 h / 20 °C

5: 89 percent / POCl₃ / 16 h / 95 °C

6: 83 percent / iPr₂NEt / dimethylsulfoxide / 16 h / 80 °C

7: 69 percent / iPr₂NEt / CH₂Cl₂ / 16 h / 20 °C

8: tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(di-tert-butylphosphino)biphenyl; NaOt-Bu / toluene / 0.23 h / 150 °C / microwave irradiation

With sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; nitric acid; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; johnphos; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene;

DOI:10.1021/jm060065y

Reference yield:

4-bromo-2-nitro-5-(trifluoromethyl)aniline (683241-86-3) → N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine (683243-08-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / SnCl₂*2H₂O / ethyl acetate; ethanol / 1 h / 70 °C

2: 97 percent / tetrahydrofuran / 16 h / 20 °C

3: 89 percent / POCl₃ / 16 h / 95 °C

4: 83 percent / iPr₂NEt / dimethylsulfoxide / 16 h / 80 °C

5: 69 percent / iPr₂NEt / CH₂Cl₂ / 16 h / 20 °C

6: tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(di-tert-butylphosphino)biphenyl; NaOt-Bu / toluene / 0.23 h / 150 °C / microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; johnphos; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;

DOI:10.1021/jm060065y

Reference yield:

5-bromo-2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole (683241-87-4) → N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine (683243-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / iPr₂NEt / dimethylsulfoxide / 16 h / 80 °C

2: 69 percent / iPr₂NEt / CH₂Cl₂ / 16 h / 20 °C

3: tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(di-tert-butylphosphino)biphenyl; NaOt-Bu / toluene / 0.23 h / 150 °C / microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; johnphos; sodium t-butanolate; In dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1021/jm060065y

upstream raw materials:

N-(4-bromo-3-trifluoromethylphenyl)acetamide

4-bromo-2-nitro-5-(trifluoromethyl)aniline

5-bromo-2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole

5-bromo-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one