41513-05-7

Basic information

• Product Name: 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE
• Synonyms: 5-ACETAMIDO-2-BROMOBENZOTRIFLUORIDE;4'-BROMO-3'-(TRIFLUOROMETHYL)ACETANILIDE;4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE;BUTTPARK 37\11-74;N1-[4-BROMO-3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE;5-Acetamido-2-bromobenzotrifluoride,97%;4'-Bromo-3'-(trifluoromethyl)acetanilide 98%;4'-Bromo-3'-(trifluoromethyl)acetanilide98%
• CAS NO: 41513-05-7
• Molecular Formula: C₉H₇BrF₃NO
• Molecular Weight: 282.06
• Mol File: 41513-05-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 116-119°C
• Boiling Point: 333.8 °C at 760 mmHg
• Flash Point: 155.7 °C
• Appearance: powder
• Density: 1.637 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.70±0.70(Predicted)
• CAS DataBase Reference: 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE(41513-05-7)
• EPA Substance Registry System: 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE(41513-05-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 41513-05-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-(trifluoromethyl)acetanilide is a chemical compound that belongs to the class of organic compounds known as acetanilides. It is recognized by its systematic IUPAC name, 4-Bromo-N-(2,2,2-trifluoroacetyl)aniline, where its ingredients are indicated. The presence of bromine suggests it's a brominated derivative and the trifluoromethyl group signifies that it is a compound containing fluorine atoms, strengthening its organic nature. It is generally used for various laboratory and commercial chemical synthesis due to its chemical stability and reactive properties. The exact properties, uses, and safety measures associated with this chemical can vary, and it is always important to handle it using appropriate safety measures.

Upstream product

• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 98-16-8 3-trifluoromethylaniline 
• 108-24-7 acetic anhydride 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 

Downstream Products

• 97760-99-1 C₁₀H₇F₃N₂O 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 40161-55-5 1-bromo-4-fluoro-2-(trifluoromethyl)benzene 
• 7657-09-2 1,4-dibromo-2-(trifluoromethyl)benzene 
• 364-11-4 1-bromo-4-iodo-2-(trifluoromethyl)benzene 
• 143782-18-7 4-isocyanato-2-(trifluoromethyl)benzonitrile 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 157590-60-8 4-bromo-5-(trifluoromethyl)benzene-1,2-diamine 
• 683243-08-5 N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine 
• 683241-86-3 4-bromo-2-nitro-5-(trifluoromethyl)aniline 
• 157554-76-2 N-[4-bromo-2-nitro-5-(trifluoromethyl)phenyl]acetamide 

Relevant articles and documents

2-bromo-5- fluorine three fluorine methylbenzene preparation method

The invention discloses a method for preparing 2-bromine-5-trifluorotoluene chloride. The method comprises the following step: under an anhydrous condition and in an organic solvent, performing cracking reaction on an anhydrous compound 1 or a compound 1', thereby preparing 2-bromine-5-trifluorotoluene chloride. According to the method, the reaction of an upper amino protecting group of m-trifluoromethyl phenylamine, the bromination reaction and the reaction of removing the amino protecting group can be all performed in one same reaction kettle without transferring or storing materials. The raw materials used in the method disclosed by the invention are cheap and easy to obtain, the reaction step is short, the reaction condition is gentle, the utilization rate of bromine is high, and the positioning selectivity of bromine feeding is high, so that a final product is low in isomeride impurity, high in reaction conversion rate, high in yield, high in product purity, low in production cost is low and applicable to industrialization production. The compound 1 and compound 1' are as shown in the specification.

HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY

The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).