Technology Process of tert-butyl 4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)benzylcarbamate
There total 5 articles about tert-butyl 4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)benzylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / 1,4-dioxane / 0.75 h / 20 - 30 °C
1.2: 0 - 80 °C
2.1: cesium fluoride; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 75 °C / Inert atmosphere
3.1: hydrogenchloride; tin / water / 0 - 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation
5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 20 h / 80 °C
With
hydrogenchloride; tin; N-Bromosuccinimide; sodium hydride; sodium carbonate; triphenylphosphine; cesium fluoride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate;
In
1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
With
sodium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; water;
at 80 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: cesium fluoride; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 75 °C / Inert atmosphere
2: hydrogenchloride; tin / water / 0 - 80 °C / Inert atmosphere
3: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation
4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 20 h / 80 °C
With
hydrogenchloride; tin; N-Bromosuccinimide; sodium carbonate; triphenylphosphine; cesium fluoride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium diacetate;
In
1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;