5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

Base Information

• Chemical Name: 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester
• CAS No.: 105544-30-7
• Molecular Formula: C9H9BrN2O5
• Molecular Weight: 305.085
• Hs Code.: 2933399090
• Mol file: 105544-30-7.mol

Synonyms:2-(5-Bromo-3-nitropyridin-2-yloxy)acetic acid ethyl ester;Ethyl-[(5-brom-3-nitropyridin-2-yl)oxy]acetate;

Chemical Property of 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

Chemical Property:

• Vapor Pressure: 1.72E-05mmHg at 25°C
• Melting Point: 63-64 °C
• Refractive Index: 1.562
• Boiling Point: 364.1 °C at 760 mmHg
• PKA: -3.22±0.32(Predicted)
• Flash Point: 174 °C
• PSA: 94.24000
• Density: 1.625 g/cm³
• LogP: 2.21740
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

There total 2 articles about 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-2-chloro-3-nitropyridine (67443-38-3) + ethyl 2-hydroxyacetate (623-50-7) → ethyl-2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate (105544-30-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1080/00397911.2013.781183

Reference yield: 62.0%

5-bromo-2-chloro-3-nitropyridine (67443-38-3) + ethyl 2-hydroxyacetate sodium salt (38233-96-4) → ethyl-2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate (105544-30-7)

Guidance literature:

Reference yield: 91.0%

ethyl-2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate (105544-30-7) → 7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (105544-36-3)

Guidance literature:

With iron; acetic acid; at 70 ℃;

upstream raw materials:

5-bromo-2-chloro-3-nitropyridine

ethyl 2-hydroxyacetate sodium salt

ethyl 2-hydroxyacetate

Downstream raw materials:

7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

7-Bromo-3-[1-phenyl-meth-(Z)-ylidene]-1H-pyrido[2,3-b][1,4]oxazin-2-one

ethyl 2-((3-nitro-5-phenylpyridin-2-yl)oxy)acetate

7-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one