3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

Base Information

Chemical Name:3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester
CAS No.:704906-49-0
Molecular Formula:C₂₅H₃₂INO₆Si
Molecular Weight:597.522
Hs Code.:

Synonyms:3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

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Chemical Property of 3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

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Technology Process of 3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

There total 6 articles about 3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 704906-45-6
3-benzyloxy-4-[2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-ynyl]-5-nitro-benzoic acid methyl ester

: 704906-49-0
3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

Guidance literature:: With pyridine; potassium diazodicarboxylate; acetic acid; In methanol; for 2h;
DOI:10.1021/ol049583y

Reference yield:

: 187682-19-5
3-benzoyloxy-4-methyl-5-nitrobenzoic acid methyl ester

: 704906-49-0
3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / dimethylformamide / 4 h / 140 °C

2: 89 percent / triethylamine; zinc(II) trifluoromethanesulfonate; (1S,2R)-(+)-N-methylephedrine / toluene / 17.5 h / 20 °C

3: 97 percent / imidazole / CH₂Cl₂ / 4 h / 20 °C

4: 87 percent / N-iodosuccinimide; silver nitrate / acetone / 0 - 20 °C

5: 95 percent / dipotassium azodicarboxylate; pyridine; acetic acid / methanol / 2 h

With pyridine; 1H-imidazole; N-iodo-succinimide; (1S,2R)-(+)-N-methylephedrine; potassium diazodicarboxylate; zinc trifluoromethanesulfonate; silver nitrate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol049583y

Reference yield:

: 704906-34-3
3-benzoyloxy-5-nitro-4-(2-oxoethyl)benzoic acid methyl ester

: 704906-49-0
3-Benzyloxy-4-[(Z)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-4-iodo-but-3-enyl]-5-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / triethylamine; zinc(II) trifluoromethanesulfonate; (1S,2R)-(+)-N-methylephedrine / toluene / 17.5 h / 20 °C

2: 97 percent / imidazole / CH₂Cl₂ / 4 h / 20 °C

3: 87 percent / N-iodosuccinimide; silver nitrate / acetone / 0 - 20 °C

4: 95 percent / dipotassium azodicarboxylate; pyridine; acetic acid / methanol / 2 h

With pyridine; 1H-imidazole; N-iodo-succinimide; (1S,2R)-(+)-N-methylephedrine; potassium diazodicarboxylate; zinc trifluoromethanesulfonate; silver nitrate; acetic acid; triethylamine; In methanol; dichloromethane; acetone; toluene;
DOI:10.1021/ol049583y