1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

Base Information

Chemical Name:1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol
CAS No.:1447004-27-4
Molecular Formula:C₂₄H₁₈F₃NO
Molecular Weight:393.408
Hs Code.:

Synonyms:1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

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Chemical Property of 1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

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Technology Process of 1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

There total 4 articles about 1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1447004-22-9
1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

: 1447004-27-4
1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

Guidance literature:: With sodium tetrahydroborate; sodium hydrogencarbonate; In methanol; for 0.666667h;
DOI:10.1002/ejoc.201300212

Reference yield:

: 67680-91-5
1-(biphenyl-4-yl)-2-phenylethanone oxime

: 1447004-27-4
1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide semihydrate / dimethyl sulfoxide / 3 h / 20 - 100 °C / 10640.7 Torr / Autoclave

2: mercury(II) diacetate / acetonitrile; water / 2.25 h / 20 - 60 °C

3: pyridine / diethyl ether / 2.5 h

4: sodium hydrogencarbonate; sodium tetrahydroborate / methanol / 0.67 h

With pyridine; sodium tetrahydroborate; potassium hydroxide semihydrate; mercury(II) diacetate; sodium hydrogencarbonate; In methanol; diethyl ether; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/ejoc.201300212

Reference yield:

: 1447004-10-5
2-(1,1-biphenyl-4-yl)-3-phenylpyrrole

: 1447004-27-4
1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / diethyl ether / 2.5 h

2: sodium hydrogencarbonate; sodium tetrahydroborate / methanol / 0.67 h

With pyridine; sodium tetrahydroborate; sodium hydrogencarbonate; In methanol; diethyl ether;
DOI:10.1002/ejoc.201300212