1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

Base Information

Chemical Name:1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone
CAS No.:1447004-22-9
Molecular Formula:C₂₄H₁₆F₃NO
Molecular Weight:391.392
Hs Code.:

Synonyms:1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

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Chemical Property of 1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

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Technology Process of 1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

There total 3 articles about 1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1447004-10-5
2-(1,1-biphenyl-4-yl)-3-phenylpyrrole

: 407-25-0
trifluoroacetic anhydride

: 1447004-22-9
1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

Guidance literature:: With pyridine; In diethyl ether; for 2.5h;
DOI:10.1002/ejoc.201300212

Reference yield:

: 67680-91-5
1-(biphenyl-4-yl)-2-phenylethanone oxime

: 1447004-22-9
1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide semihydrate / dimethyl sulfoxide / 3 h / 20 - 100 °C / 10640.7 Torr / Autoclave

2: mercury(II) diacetate / acetonitrile; water / 2.25 h / 20 - 60 °C

3: pyridine / diethyl ether / 2.5 h

With pyridine; potassium hydroxide semihydrate; mercury(II) diacetate; In diethyl ether; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/ejoc.201300212

Reference yield:

: 1447004-15-0
1-vinyl-2-(1,1-biphenyl-4-yl)-3-phenylpyrrole

: 1447004-22-9
1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: mercury(II) diacetate / acetonitrile; water / 2.25 h / 20 - 60 °C

2: pyridine / diethyl ether / 2.5 h

With pyridine; mercury(II) diacetate; In diethyl ether; water; acetonitrile;
DOI:10.1002/ejoc.201300212