(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

Base Information

Chemical Name:(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine
CAS No.:1572246-72-0
Molecular Formula:C₃₀H₄₄N₂O₅SSi
Molecular Weight:572.841
Hs Code.:

Synonyms:(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

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Technology Process of (S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

There total 7 articles about (S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5457-29-4
N-(3-iodopropyl)phthalimide

: 1572246-69-5
(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-tosylpentanamine

: 1572246-72-0
(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 17h;
DOI:10.1021/jo5002627

Reference yield:

: 1572246-44-6
(S)-4-methyl-5-[(p-methylbenzenesulfonyl)amino]-1-pentanol

: 1572246-72-0
(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 15 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C

With 1H-imidazole; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo5002627

Reference yield:

: 1572246-13-9
(S)-5-{[(1R)-2-hydroxy-1-phenylethyl]amino}-4-methyl-1-pentanol

: 1572246-72-0
(S)-5-[(tert-butyldimethylsilyl)oxy]-2-methyl-N-[3-(phthalimido)propyl]-N-tosylpentanamine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium(II) hydroxide; hydrogen / methanol / 18 h / 68 °C / 7500.75 Torr

2: triethylamine / dichloromethane / 15 h / 20 °C

3: 1H-imidazole / dichloromethane / 15 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C

With 1H-imidazole; hydrogen; palladium(II) hydroxide; sodium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo5002627