Technology Process of (S)-2-methyl-N-[3-(phthalimido)propyl]-N-tosyl-5-hexenamine
There total 10 articles about (S)-2-methyl-N-[3-(phthalimido)propyl]-N-tosyl-5-hexenamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
C24H28N2O5S;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
DOI:10.1021/jo5002627
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium sulfate / diethyl ether / 5 h / 0 °C
2.1: n-butyllithium; borane-ammonia complex / tetrahydrofuran; hexane / 1 h / 0 - 40 °C
3.1: palladium(II) hydroxide; hydrogen / methanol / 18 h / 68 °C / 7500.75 Torr
4.1: triethylamine / dichloromethane / 15 h / 20 °C
5.1: 1H-imidazole / dichloromethane / 15 h / Reflux
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C
7.1: hydrogenchloride / water / 0.33 h / 20 °C
8.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C
9.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C
9.2: 3 h / 20 °C
With
1H-imidazole; hydrogenchloride; n-butyllithium; borane-ammonia complex; potassium tert-butylate; hydrogen; palladium(II) hydroxide; sodium hydride; Dess-Martin periodane; sodium sulfate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo5002627
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 15 h / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / 20 °C
3.1: hydrogenchloride / water / 0.33 h / 20 °C
4.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C
5.2: 3 h / 20 °C
With
1H-imidazole; hydrogenchloride; potassium tert-butylate; sodium hydride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo5002627
