Tetracosactide acetate

Base Information

• Chemical Name: Tetracosactide acetate
• CAS No.: 16960-16-0
• Molecular Formula: C136H210N40O31S
• Molecular Weight: 2933.46
• Hs Code.: 2937220000
• Wikidata: Q560542
• Mol file: 16960-16-0.mol

Synonyms:1-24-ACTH;1-24-Corticotropin;ACTH (1-24);ACTH 1-24;ACTH, Synthetic;Corticotropin (1-24)-Peptide;Corticotropin (1-24)-Tetracosapeptide;Cortosyn;Cortrosyn;Cosyntropin;Synthetic ACTH;Tetracosactide;Tetracosactrin;Tetracosapeptide

Chemical Property of Tetracosactide acetate

Chemical Property:

• Refractive Index: 1.681
• PSA: 1184.02000
• Density: 1.476 g/cm³
• LogP: 6.74150
• Storage Temp.: −20°C
• Solubility.: Sparingly soluble in water.
• Water Solubility.: Soluble in water
• XLogP3: -7.9
• Hydrogen Bond Donor Count: 42
• Hydrogen Bond Acceptor Count: 41
• Rotatable Bond Count: 96
• Exact Mass: 2932.5839961
• Heavy Atom Count: 208
• Complexity: 6500

Purity/Quality:

98% ^*data from raw suppliers

Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N
• Recent ClinicalTrials: Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis
• Recent EU Clinical Trials: ESYBRECHE : Evaluation de l’efficacité et de la tolérance du tetracosactide Synacthène? dans le traitement des syndromes post-brèche dure-méro-arachno?dienne
• Description: Cosyntropin is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.
• Uses: Adrenocorticotropic Hormone (1-24), human is used in the treatment of West syndrome. It activates G proteins. It stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells. It also enhances transcription of mitochondrial genes. Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.
• Indications: Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.