9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

Base Information

Chemical Name:9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
CAS No.:234436-54-5
Molecular Formula:C₃₆H₃₀FN₅O₄S
Molecular Weight:647.73
Hs Code.:

Synonyms:9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

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Chemical Property of 9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

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Technology Process of 9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

There total 11 articles about 9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1005-56-7
phenylcarbonochloridothioate

: 239811-11-1
9-(5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

: 234436-54-5
9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

Guidance literature:: With dmap; In acetonitrile;
DOI:10.1016/S0040-4039(01)00135-6 DOI:10.1081/NCN-120021951

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 234436-54-5
9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 38 percent / DMAP / CH₂Cl₂

2.1: pyridine / toluene

2.2: 70 percent / Et₃N / toluene

3.1: 78 percent / (diethylamino)sulfur trifluoride; pyridine / CH₂Cl₂ / Heating

4.1: 98 percent / NH₃ / methanol

5.1: 92 percent / DMAP / acetonitrile

With pyridine; dmap; diethylamino-sulfur trifluoride; ammonia; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1081/NCN-120021951

Reference yield:

: 234436-48-7
9-[3-O-benzoyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl]-6-chloro-9H-purine

: 234436-54-5
9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / (diethylamino)sulfur trifluoride; pyridine / CH₂Cl₂ / Heating

2: 98 percent / NH₃ / methanol

3: 92 percent / DMAP / acetonitrile

With pyridine; dmap; diethylamino-sulfur trifluoride; ammonia; In methanol; dichloromethane; acetonitrile;
DOI:10.1081/NCN-120021951