(S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

Base Information

Chemical Name:(S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate
CAS No.:181637-44-5
Molecular Formula:C₄₀H₄₅NO₆
Molecular Weight:635.8
Hs Code.:

Synonyms:(S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

Chemical Property:

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Technology Process of (S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

There total 1 articles about (S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 541-16-2
t-butyl malonate

: 181637-41-2
N-trityl-β-iodo-α-alanine benzyl ester

: 67413-25-6
benzyl (-)-(2S)-1-trityl-aziridine-2-carboxylate

: 181637-44-5
(S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

Guidance literature:: t-butyl malonate; With sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 0.5h;

N-trityl-β-iodo-α-alanine benzyl ester; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 40 ℃; for 12h;
DOI:10.1021/jo960624g

Reference yield:

: 181637-44-5
(S)-1-benzyl-5,5'-di-tert-butyl-N-(triphenylmethyl)-4-carboxyglutamate

: 111662-65-8
N-α-(9-fluorenylmethoxycarbonyl)-L-γ-carboxy-glutamic acid-γ,γ-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium black / ethyl acetate; methanol / 8 h / 20 °C / 1875.15 Torr

2: 713 mg / diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium; In tetrahydrofuran; methanol; ethyl acetate; 1: Hydrogenolysis / 2: alkoxycarbonylation;
DOI:10.1021/jo960624g