67413-25-6

Upstream product

• 135248-89-4 N^α-fluoren-9-ylmethoxycarbonyl-L-cysteine 
• 181637-41-2 N-trityl-β-iodo-α-alanine benzyl ester 
• 164121-45-3 (S)-Boc-Penicillamine methyl ester 
• 172322-96-2 (R)-tert-butyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-mercaptopropanoate 
• 84771-33-5 (2S)-1-trityl-aziridine-2-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 60022-62-0 L-serine benzyl ester hydrochloride 
• 76-83-5 trityl chloride 
• 139592-37-3 (2R,2‘R)-di-tert-butyl 3,3‘-disulfanediylbis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoate) 
• 135273-01-7 N,N'-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cystine 
• 263402-36-4 (S)-β-Chloroaniline benzyl ester 
• 541-16-2 t-butyl malonate 
• 1694-31-1 tert-butyl acetoacetate 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 83824-80-0 benzyl (2S)-1-benzyloxycarbonyl-aziridine-2-carboxylate 
• 84771-33-5 (2S)-1-trityl-aziridine-2-carboxylic acid 
• 67413-26-7 L-aziridine-2-carboxylic acid benzyl ester 
• 69876-37-5 (S)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoate 
• 126496-87-5 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-1H-indol-3-yl)-propionic acid benzyl ester 
• 126496-85-3 (S)-2-Benzyloxycarbonylamino-3-(4-methoxy-1H-indol-3-yl)-propionic acid benzyl ester 
• 126496-82-0 (S)-2-Benzyloxycarbonylamino-3-(5-methyl-1H-indol-3-yl)-propionic acid benzyl ester 
• 157878-50-7 (S)-1-Trityl-aziridine-2-carboxylic acid pentafluorophenyl ester 

Relevant academic research and scientific papers

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers

Three γ-heteroatom-substituted N-methylpyrroletetrazole-lysines (mPyTXKs) were synthesized and subsequently incorporated into proteins site-specifically via genetic code expansion. The γ-seleno-substituted derivative, mPyTSeK, showed excellent incorporati

A convenient method of preparing optically active (S)-N-tritylaziridine- 2-carboxylate esters from (S)-β-haloamino acids

A convenient method of preparing optically active (S)-N-tritylaziridine- 2-carboxylate esters via intramolecular cyclization of (S)-N-trityl-β- haloamino acid esters is described.

Synthesis of natural and non natural orthogonally protected lanthionines from N-tritylserine and allo-threonine derivatives

The reactivity of electrophiles derived from N-tritylserine, threonine and allothreonine esters toward a selection of nucleophiles was investigated. Best yields from substitution products were obtained with N-trityliodoalanine and soft nucleophiles such a

One-step synthesis of optically active benzyl N-trityl-L-aziridine-2-carboxylic esters

Benzyl N-trityl-L-serine or threonine esters give upon treatment with sulphuryl chloride the corresponding benzyl (2s)-1-trityl-2-aziridine carboxylate or (2S, 3S)-1-trityl-3-methyl-2-aziridinecarboxylate esters in excellent yields.