N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Base Information

• Chemical Name: N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
• CAS No.: 170236-39-2
• Molecular Formula: C₃₅H₃₇N₅O₇
• Molecular Weight: 639.708

Synonyms:N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Chemical Property of N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Chemical Property:

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Technology Process of N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

There total 22 articles about N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine (170236-40-5) → 5-O-(4,4-dimethoxytriphenyl)-N-2-isobutyryl-2-desoxyxyloguanosine (170236-39-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h;

DOI:10.1002/anie.201310644

Reference yield: 97.0%

[(2R,3R,5R)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo- 1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate (170236-40-5) → N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide (170236-39-2)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 1h;

Reference yield: 90.0%

5'-dimethoxytrityl-2'-tosyl-N2-isobutyrylguanosine (719288-75-2) → N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide (170236-39-2)

Guidance literature:

With L-Selectride; In tetrahydrofuran; for 2h; cooling;

DOI:10.1081/NCN-120027826

upstream raw materials:

Methanesulfonic acid (2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine

N²-isobutyryl-2'-O-methanesulfonylguanosine

N²-isobutyryl-2'-O-p-toluenesulfonylguanosine

Downstream raw materials:

3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thio-guanosine-3'-S-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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