5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

Base Information

• Chemical Name: 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine
• CAS No.: 170236-40-5
• Molecular Formula: C₄₂H₄₁N₅O₈
• Molecular Weight: 743.816

Synonyms:5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

Chemical Property of 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

There total 7 articles about 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 3-O-benzoyl-2-desoxyxyloguanosine (121513-00-6) → 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine (170236-40-5)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1002/anie.201310644

Reference yield: 88.7%

sodium benzoate (532-32-1) + 3'-O(R)-(methylsulfonyl)-N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1187644-19-4) → [(2R,3R,5R)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo- 1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate (170236-40-5)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃;

Reference yield: 85.9%

4,4'-dimethoxytrityl chloride (40615-36-9) + [(2R,3R,5R)-2-(hydroxymethyl)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate (121513-00-6) → [(2R,3R,5R)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo- 1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate (170236-40-5)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

upstream raw materials:

sodium benzoate

3'-O(R)-(methylsulfonyl)-N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

N-isobutyryl-2'-deoxyguanosine

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

Downstream raw materials:

N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

5-O-(4,4-dimethoxytriphenyl)-N-2-isobutyryl-2-desoxyxyloguanosine

3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 170236-40-5 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send