2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

Base Information

Chemical Name:2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine
CAS No.:90742-23-7
Molecular Formula:C₄₃H₄₅N₃O₁₀
Molecular Weight:763.844
Hs Code.:

2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N<sup>4</sup>-anysoylcytidine

Synonyms:2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

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Technology Process of 2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

There total 5 articles about 2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 90742-22-6
2'-O-(tetrahydropyran-2-yl)-N⁴-anysoylcytidine

: 90742-23-7
2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

Guidance literature:: With pyridine; for 0.666667h;
DOI:10.1021/ja00328a042

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 90742-23-7
2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / dioxane / 11 h

2: pyridine / 0.58 h / 0 °C

3: Et₄NBr, KF, H₂O / acetonitrile / 0.5 h / 96 °C

4: 96 percent / pyridine / 0.67 h

With pyridine; potassium fluoride; tetraethylammonium bromide; water; trifluoroacetic acid; In 1,4-dioxane; pyridine; acetonitrile;
DOI:10.1021/ja00328a042

Reference yield:

: 90742-20-4
2'-O-tetrahydropyranyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

: 90742-23-7
2'-O-(tetrahydropyran-2-yl)-5-O'-(4,4'-dimethoxytrityl)-N⁴-anysoylcytidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0.58 h / 0 °C

2: Et₄NBr, KF, H₂O / acetonitrile / 0.5 h / 96 °C

3: 96 percent / pyridine / 0.67 h

With pyridine; potassium fluoride; tetraethylammonium bromide; water; In pyridine; acetonitrile;
DOI:10.1021/ja00328a042