(E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

Base Information

• Chemical Name: (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine
• CAS No.: 234762-40-4
• Molecular Formula: C₃₅H₃₁N₃O₄
• Molecular Weight: 557.649
• Mol file: 234762-40-4.mol

Synonyms:(E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

Chemical Property of (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

There total 3 articles about (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(Z)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine (234762-41-5) → (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine (234762-40-4)

Guidance literature:

With nitroacetic acid ethyl ester; sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 120h;

Reference yield: 43.0%

nitroacetic acid ethyl ester (626-35-7) + 5a,6,7,9a-Tetrahydro-5,6-tetramethylene-7,9-diphenyl-5H-naphtho[1',2':4,5]imidazo[1,2-a]pyridine (138792-73-1) → (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine (234762-40-4) + (Z)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine (234762-41-5)

Guidance literature:

With manganese(IV) oxide; In acetone; for 0.75h;

Reference yield:

5a,6,7,9a-Tetrahydro-5,6-tetramethylene-7,9-diphenyl-5H-naphtho[1',2':4,5]imidazo[1,2-a]pyridine (138792-73-1) → (E)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine (234762-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / MnO₂ / acetone / 0.75 h

2: 69 percent / Na₂CO₃; ethyl nitroacetate / dimethylformamide / 120 h / 20 °C

With manganese(IV) oxide; nitroacetic acid ethyl ester; sodium carbonate; In N,N-dimethyl-formamide; acetone; 1: Condensation / 2: Isomerization;

upstream raw materials:

nitroacetic acid ethyl ester

5a,6,7,9a-Tetrahydro-5,6-tetramethylene-7,9-diphenyl-5H-naphtho[1',2':4,5]imidazo[1,2-a]pyridine

(Z)-5a,6,7,9a-Tetrahydro-5a,6-tetramethylene-11-[ethoxycarbonyl(nitro)methylene]naphtho[1',2':4,5]imidazo[1,2-a]pyridine

Downstream raw materials:

C₃₄H₂₆N₄