1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS No.:1601220-16-9
Molecular Formula:C₃₀H₃₁N₃O₅
Molecular Weight:513.593
Hs Code.:

Synonyms:1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Chemical Property of 1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Technology Process of 1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

There total 6 articles about 1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1601220-07-8
1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

: 1601220-16-9
1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: With boron tribromide; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.046

Reference yield:

: 26759-46-6
methyl 2-amino-4,5-dimethoxybenzoate

: 1601220-16-9
1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / dichloromethane; methanol / 1 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: sodium methylate / methanol / 20 °C

4: 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

5: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With sodium methylate; boron tribromide; acetic acid; triethylamine; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;
DOI:10.1016/j.bmc.2014.02.046

Reference yield:

: 100-52-7
benzaldehyde

: 1601220-16-9
1-benzyl-N-((1-benzylpiperidin-4-yl)methyl) 4,6,7-trihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / dichloromethane; methanol / 1 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: sodium methylate / methanol / 20 °C

4: 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

5: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With sodium methylate; boron tribromide; acetic acid; triethylamine; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;
DOI:10.1016/j.bmc.2014.02.046