methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate
CAS No.:1596341-40-0
Molecular Formula:C₂₈H₂₃F₃N₂O₄
Molecular Weight:508.497
Hs Code.:

Synonyms:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Chemical Property of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Technology Process of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

There total 12 articles about methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1596341-39-7
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-40-0
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.75h;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596341-40-0
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 90 °C / Inert atmosphere

6.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 °C

7.1: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl acetamide; cyclohexane; water; mineral oil;

Reference yield:

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1596341-40-0
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(3-phenyl-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 90 °C / Inert atmosphere

3: methanol / cyclohexane; diethyl ether / 0.5 h / 0 °C

4: sodium tetrahydroborate / methanol / 0.75 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl acetamide; cyclohexane; water; mineral oil;