6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%

Base Information

• Chemical Name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%
• CAS No.: 1002727-88-9
• Molecular Formula: C15H21BO3
• Molecular Weight: 260.141
• Hs Code.: 2934999090
• Mol file: 1002727-88-9.mol

Synonyms:6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%;3,4-Dihydro-2H-chromene-6-boronic acid, pinacol ester, 3,4-Dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-chromene;Chroman-6-boronic acid, pinacol ester;2-(ChroMan-6-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Chemical Property of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%

Chemical Property:

• Boiling Point: 373.5±31.0 °C(Predicted)
• PSA: 27.69000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 2.31080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%

There total 5 articles about 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-iodo-chroman (67856-45-5) + bis(pinacol)diborane (73183-34-3) → 2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1002727-88-9)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 95 ℃; for 5.16667h;

Reference yield: 84.0%

chromane (493-08-3) + bis(pinacol)diborane (73183-34-3) → 2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1002727-88-9)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 95 ℃; for 5h;

Reference yield: 63.9%

→ 2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1002727-88-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In toluene; Reflux;

upstream raw materials:

6-iodo-chroman

bis(pinacol)diborane

chromane

6-bromo-chroman

Downstream raw materials:

C₃₂H₃₃NO₅

5-(3,4-dihydro-2H-1-benzopyran-6-yl)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde

methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate

methyl 2-(tert-butoxy)-2-[5-(3,4-dihydro-2H-1-benzopyran-6-yl)-2-phenyl-1,3-thiazol-4-yl]acetate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK". Page/Page column 72. . Retrieved 2012/09/21.
• 2、 -. "INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 76. . Retrieved 2009/06/27.