(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Base Information

Chemical Name:(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane
CAS No.:108868-63-9
Molecular Formula:C₂₉H₄₈N₂O₅
Molecular Weight:504.711
Hs Code.:

Synonyms:(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Suppliers and Price of (3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

There total 7 articles about (3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 108868-94-6
[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butyl]-carbamic acid tert-butyl ester

: 108868-63-9
(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 75h;
DOI:10.1021/jm00390a018

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 108868-63-9
(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 15 min

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 5A molecular sieves / tetrahydrofuran / 24 h

4: NaCNBH₃ / tetrahydrofuran / 0.5 h / 0 °C

5: 72 percent / Et₃N / CH₂Cl₂ / 75 h / 0 - 20 °C

With 5A molecular sieve; ammonia; hydrogen; sodium cyanoborohydride; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00390a018

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 108868-63-9
(3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / methanol; H₂O / 18 h / Ambient temperature

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 5A molecular sieves / tetrahydrofuran / 24 h

4: NaCNBH₃ / tetrahydrofuran / 0.5 h / 0 °C

5: 72 percent / Et₃N / CH₂Cl₂ / 75 h / 0 - 20 °C

With 5A molecular sieve; ammonia; hydrogen; sodium cyanoborohydride; triethylamine; nickel; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00390a018