5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine
CAS No.:1417895-16-9
Molecular Formula:C₂₆H₂₀F₃N₃O₂
Molecular Weight:463.459
Hs Code.:

Synonyms:5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of 5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

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Technology Process of 5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

There total 3 articles about 5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 624-31-7
4-tolyl iodide

: 1417895-08-9
5-(furan-2-yl)-3-(4-methoxybenzyl)-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

: 1417895-16-9
5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: With bis(triphenylphosphine)nickel(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 8h; Time; Reagent/catalyst; Inert atmosphere;
DOI:10.1055/s-0032-1317329

Reference yield:

: 3-(4-methoxybenzyl)-3H-imidazol-4-ylamine

: 1417895-16-9
5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 5 h / Inert atmosphere; Schlenk technique; Reflux

2: bis(triphenylphosphine)nickel(II) chloride; potassium carbonate / N,N-dimethyl-formamide / 8 h / 110 °C / Inert atmosphere

With bis(triphenylphosphine)nickel(II) chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317329

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1417895-16-9
5-(furan-2-yl)-3-(4-methoxybenzyl)-2-p-tolyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h / Inert atmosphere; Schlenk technique; Reflux

2: dichloromethane / 5 h / Inert atmosphere; Schlenk technique; Reflux

3: bis(triphenylphosphine)nickel(II) chloride; potassium carbonate / N,N-dimethyl-formamide / 8 h / 110 °C / Inert atmosphere

With bis(triphenylphosphine)nickel(II) chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317329