(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

Base Information

Chemical Name:(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile
CAS No.:1220704-89-1
Molecular Formula:C₁₉H₁₃F₃N₂O
Molecular Weight:342.32
Hs Code.:

Synonyms:(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

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Chemical Property of (S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

Chemical Property:

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Technology Process of (S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

There total 4 articles about (S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 61637-11-4,144017-74-3
(2E)-1-phenyl-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

: 109-77-3
malononitrile

: 1220704-89-1
(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

Guidance literature:: With quinine; In toluene; at -18 ℃; for 70h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.200900712

Reference yield:

: 61637-11-4
3-(4-(trifluoromethyl)phenyl)-1-phenylprop-2-en-1-one

: 109-77-3
malononitrile

: 1220704-89-1
(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

: 1300747-59-4
(R)-2-(1-(4-trifluoromethylphenyl)-3-oxo-3-phenylpropyl)malononitrile

Guidance literature:: With C₂₆H₃₄F₆N₄O₃SSi; In toluene; at 20 ℃; for 168h; Overall yield = 96 %; enantioselective reaction;
DOI:10.1016/j.tetasy.2017.05.015

Reference yield:

: 61637-11-4,144017-74-3
(2E)-1-phenyl-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

: 109-77-3
malononitrile

: 1220704-89-1
(S)-2-(3-oxo-3-phenyl-1-(4-(trifluoromethyl)phenyl)propyl)malononitrile

: 1300747-59-4
(R)-2-(1-(4-trifluoromethylphenyl)-3-oxo-3-phenylpropyl)malononitrile

Guidance literature:: With (S)-(-)-α,α-di(2-naphthyl)-2-pyrrolidinemethanol; In toluene; at -18 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/ejoc.201001466