allyl 2-diazo-2-(4-methoxyphenyl)acetate

Base Information

• Chemical Name: allyl 2-diazo-2-(4-methoxyphenyl)acetate
• CAS No.: 1206707-09-6
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Mol file: 1206707-09-6.mol

Synonyms:allyl 2-diazo-2-(4-methoxyphenyl)acetate

Chemical Property of allyl 2-diazo-2-(4-methoxyphenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-diazo-2-(4-methoxyphenyl)acetate

There total 2 articles about allyl 2-diazo-2-(4-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4'-Methoxyphenylessigsaeureallylester (15727-84-1) → allyl 2-diazo-2-(4-methoxyphenyl)acetate (1206707-09-6)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.06.026

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → allyl 2-diazo-2-(4-methoxyphenyl)acetate (1206707-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 23 °C / Inert atmosphere

2: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere

With dmap; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile; 1: |Steglich Esterification;

DOI:10.1016/j.tetlet.2016.01.020

Reference yield: 88.0%

allyl 2-diazo-2-(4-methoxyphenyl)acetate (1206707-09-6) + (trifluoromethyl)trimethylsilane (81290-20-2) → allyl 3,3,3-trifluoro-2-(4-methoxyphenyl)propanoate (1398181-14-0)

Guidance literature:

(trifluoromethyl)trimethylsilane; With copper(l) iodide; cesium fluoride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

allyl 2-diazo-2-(4-methoxyphenyl)acetate; With water; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ja307058c

upstream raw materials:

4'-Methoxyphenylessigsaeureallylester

4-Methoxyphenylacetic acid

Downstream raw materials:

allyl 2-(1H-indol-2-yl)-2-(4-methoxyphenyl)acetate

allyl 3,3,3-trifluoro-2-(4-methoxyphenyl)propanoate