2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Base Information

Chemical Name:2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)
CAS No.:1443300-28-4
Molecular Formula:C₂₅H₃₃N₃O₇
Molecular Weight:487.553
Hs Code.:

Synonyms:2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

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Chemical Property of 2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

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Technology Process of 2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

There total 8 articles about 2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1443052-72-9
3,4-dihydroxy-1-(4-methoxyphenyl)-N²,N²,N⁵,N⁵-tetramethyl-1H-pyrrole-2,5-dicarboxamide

: 79-30-1
isobutyryl chloride

: 1443300-28-4
2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 3h;

Reference yield:

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

: 1443300-28-4
2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 1 h / 100 °C

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 72 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 0 - 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1443300-28-4
2,5-bis(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

2.1: sodium ethanolate / ethanol / 1 h / 100 °C

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 72 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 0 - 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;