(E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate

Base Information

• Chemical Name: (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate
• CAS No.: 1141997-90-1
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.354
• Mol file: 1141997-90-1.mol

Synonyms:(E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate

Chemical Property of (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate

Chemical Property:

Purity/Quality:

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Technology Process of (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate

There total 1 articles about (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methyl-benzaldehyde (104-87-0) + (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate (43189-38-4,43189-39-5) → (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate (1141997-90-1)

Guidance literature:

In toluene; Reflux; Large scale reaction;

DOI:10.1021/op800308t

Reference yield: 80.0%

methanesulfonic acid (75-75-2,98527-29-8) + (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate (1141997-90-1) + allyl bromide (106-95-6) → ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate (611227-60-2)

Guidance literature:

(E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate; allyl bromide; With lithium tert-butoxide; In tetrahydrofuran; at -5 ℃; for 1.5h; Large scale reaction;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; Large scale reaction;

methanesulfonic acid; In ethyl acetate; isopropyl alcohol; at 50 ℃; for 1h; Cooling; Large scale reaction;

DOI:10.1021/op800308t

upstream raw materials:

4-methyl-benzaldehyde

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate

Downstream raw materials:

ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate