ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Base Information

• Chemical Name: ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate
• CAS No.: 611227-60-2
• Molecular Formula: CH₄O₃S*C₁₃H₁₇NO₃
• Molecular Weight: 331.39
• Mol file: 611227-60-2.mol

Synonyms:ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Chemical Property of ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate

There total 2 articles about ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanesulfonic acid (75-75-2,98527-29-8) + (E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate (1141997-90-1) + allyl bromide (106-95-6) → ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate (611227-60-2)

Guidance literature:

(E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate; allyl bromide; With lithium tert-butoxide; In tetrahydrofuran; at -5 ℃; for 1.5h; Large scale reaction;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; Large scale reaction;

methanesulfonic acid; In ethyl acetate; isopropyl alcohol; at 50 ℃; for 1h; Cooling; Large scale reaction;

DOI:10.1021/op800308t

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate (43189-38-4,43189-39-5) → ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate (611227-60-2)

Guidance literature:

In ethyl acetate; isopropyl alcohol; at 0 - 60 ℃; for 3h;

Reference yield: 45.0%

ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate (611227-60-2) + methanesulfonic acid (75-75-2,98527-29-8) → (R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate (611227-63-5)

Guidance literature:

ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate; With sodium hydroxide; 2-amino-2-hydroxymethyl-1,3-propanediol; In water; at 38 ℃; for 2.5h; Resolution of racemate; Large scale reaction;

methanesulfonic acid; In ethyl acetate; isopropyl alcohol; at 10 ℃; for 1h; optical yield given as %ee; Large scale reaction;

DOI:10.1021/op800308t

upstream raw materials:

methanesulfonic acid

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate

(E)-ethyl 2-(4-hydroxyphenyl)-2-(4-methylbenzylideneamino)acetate

allyl bromide

Downstream raw materials:

C₁₃H₁₇NO₃

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)pent-4-enoate methane sulfonate