(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

Base Information

Chemical Name:(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one
CAS No.:1352051-03-6
Molecular Formula:C₂₃H₁₉F₅N₂O₂
Molecular Weight:450.408
Hs Code.:

Synonyms:(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

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Chemical Property of (E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

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Technology Process of (E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

There total 3 articles about (E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 376608-66-1
(E)-3-(3,4-difluorophenyl)acryloyl chloride

: 1352050-79-3
(E)-1-(piperazin-1-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1352051-03-6
(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.2174/157018011797655205

Reference yield:

: 1146354-41-7
tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

: 1352051-03-6
(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 12 h / Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.2174/157018011797655205

Reference yield:

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 1352051-03-6
(E)-3-(3,4-difluorophenyl)-1-(4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)piperazino)-2-propen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / Inert atmosphere

3: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.2174/157018011797655205