tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate
CAS No.:1146354-41-7
Molecular Formula:C₁₉H₂₃F₃N₂O₃
Molecular Weight:384.398
Hs Code.:

Synonyms:tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

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Chemical Property of tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

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Technology Process of tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

There total 5 articles about tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 192130-33-9
1-(naphthalen-1-ylsulfonyl)piperazine

: 2062-26-2,87212-84-8,16642-92-5
3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid

: 1146354-41-7
tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In Dichlorofluoromethane; at 20 ℃; for 0.666667h;
DOI:10.1021/jm900063x

Reference yield: 85.0%

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1146354-41-7
tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.2174/157018011797655205

Reference yield: 56.21%

: 120681-07-4,105919-36-6
3-(4-trifluoromethyl-phenyl)-acryloyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1146354-41-7
tert-butyl 4-((E)-3-[4-(trifluoromethyl)phenyl]-2-propenoyl)-1-piperazinecarboxylate

Guidance literature:: 1-t-Butoxycarbonylpiperazine; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

3-(4-trifluoromethyl-phenyl)-acryloyl chloride; In dichloromethane; at 20 ℃; for 12h;