3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione

Base Information

• Chemical Name: 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione
• CAS No.: 1233032-09-1
• Molecular Formula: C₁₄H₉F₆NO₃
• Molecular Weight: 353.221
• Mol file: 1233032-09-1.mol

Synonyms:3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione

Chemical Property of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione

There total 2 articles about 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione (1233032-09-1)

Guidance literature:

With zinc trifluoromethanesulfonate; In ethanol; at 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202000153

Reference yield:

3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione (1233032-09-1) + 3,4-bis((3,5-bis(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione (1233032-05-7)

Guidance literature:

With magnesium triflate; In N,N-dimethyl-formamide; toluene; at 100 ℃; for 12h;

DOI:10.1021/jo100104g

Reference yield: 96.0%

p-aminomethylbenzoic acid (56-91-7) + 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione (1233032-09-1) → 3,5-bis[trifluoromethyl]phenyl squaramide-4-aminomethyl benzoic acid

Guidance literature:

With sodium carbonate; In ethanol; at 135 ℃; for 0.583333h; Microwave irradiation; Sealed tube;

DOI:10.1039/c9ob02085c

upstream raw materials:

3,4-diethoxy-3-cyclobuten-1,2-dione

3,5-Bis-(trifluoromethyl)aniline

Downstream raw materials:

C₁₈H₁₀F₆N₂O₂

C₃₀H₂₀F₁₂N₄O₄

C₂₅H₂₅F₆N₃O₂