Technology Process of 4-(3-(3,5-cis-dimethlpiperidin-1-yl)-3-oxo-1-(2,4,6-trimethoxyphenyl)-propyl)benzoic acid
There total 6 articles about 4-(3-(3,5-cis-dimethlpiperidin-1-yl)-3-oxo-1-(2,4,6-trimethoxyphenyl)-propyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3-(3,5-cis-dimethylpiperidin-1-yl)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-oxopropyl)benzoic acid; methyl iodide;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 8h;
With
lithium hydroxide;
In
tetrahydrofuran; methanol; water;
With
hydrogenchloride;
In
water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: [2,2]bipyridinyl; palladium diacetate / acetic acid; N,N-dimethyl acetamide / 24 h / 110 °C
2: N,N-dimethyl acetamide / 6 h / 80 °C
3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
With
[2,2]bipyridinyl; palladium diacetate; potassium carbonate;
In
N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N,N-dimethyl acetamide / 6 h / 80 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
With
potassium carbonate;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide;