N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

Base Information

Chemical Name:N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide
CAS No.:133863-94-2
Molecular Formula:C₁₈H₂₅N₅O₄S
Molecular Weight:407.494
Hs Code.:

Synonyms:N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

Suppliers and Price of N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

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Technology Process of N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

There total 6 articles about N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 133863-97-5
α-[(4-Aminophenoxy)methyl]-4-(2-pyrimidinyl)-1-piperazineethanol

: 124-63-0
methanesulfonyl chloride

: 133863-94-2
N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

Guidance literature:: With pyridine; at 25 ℃; for 1.5h;
DOI:10.1021/jm00115a010

Reference yield:

: 20980-22-7
N-(2-pyridinyl)piperazine

: 133863-94-2
N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / acetonitrile / Heating

2: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 5 h

3: 44 percent / pyridine / 1.5 h / 25 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethyl acetate; acetonitrile;
DOI:10.1021/jm00115a010

Reference yield:

: 1568-66-7
1-allyloxy-4-nitrobenzene

: 133863-94-2
N-<4-<2-hydroxy-3-<4-(2-pyrimidinyl)-1-piperazinyl>propoxy>phenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

2: 62 percent / acetonitrile / Heating

3: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 5 h

4: 44 percent / pyridine / 1.5 h / 25 °C

With pyridine; hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm00115a010