ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

Base Information

Chemical Name:ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside
CAS No.:1451181-02-4
Molecular Formula:C₃₀H₃₂F₂O₇S
Molecular Weight:574.643
Hs Code.:

Synonyms:ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

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Chemical Property of ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

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Technology Process of ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

There total 3 articles about ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1451181-01-3
ethyl 4,6-O-benzylidene-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

: 1451181-02-4
ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

Guidance literature:: ethyl 4,6-O-benzylidene-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside; With borane-THF; at 0 ℃; for 0.166667h; Inert atmosphere;

With copper(II) bis(trifluoromethanesulfonate); at 0 ℃; for 25.5h; Inert atmosphere;
DOI:10.1021/ja405990z

Reference yield:

: 454664-77-8
ethyl 4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

: 1451181-02-4
ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; pyridine / 44 h / 20 °C / Inert atmosphere

2.1: borane-THF / 0.17 h / 0 °C / Inert atmosphere

2.2: 25.5 h / 0 °C / Inert atmosphere

With pyridine; dmap; borane-THF;
DOI:10.1021/ja405990z

Reference yield:

: 35730-09-7
2,5-difluorobenzoyl chloride

: 1451181-02-4
ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; pyridine / 44 h / 20 °C / Inert atmosphere

2.1: borane-THF / 0.17 h / 0 °C / Inert atmosphere

2.2: 25.5 h / 0 °C / Inert atmosphere

With pyridine; dmap; borane-THF;
DOI:10.1021/ja405990z