454664-77-8

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 142924-31-0 S-ethyl 4,6-O-benzylidene-1-thio-α-D-mannopyranoside 

Downstream Products

• 1451181-01-3 ethyl 4,6-O-benzylidene-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 
• 1451181-03-5 ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-1-thio-α-D-mannopyranoside 
• 1451181-02-4 ethyl 4-O-benzyl-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 
• 454664-79-0 ethyl O-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1->3)-2-O-benzyl-4,6-O-benzylidene-1-thio-α-D-mannopyranoside 
• 454664-78-9 ethyl 2-O-benzyl-4,6-O-benzylidene-1-thio-α-D-mannopyranoside 
• 218937-72-5 ethyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside 

Relevant academic research and scientific papers

Synthesis of the tetrasaccharide Glc α (1→3) Man α (1→2) Man α (1→2) Man α (OMe) as inhibitor of calnexin binding to GlcMan9GlcNAc2

Tetrasaccharide GlcMan3 is an inhibitor of GlcMan9GlcNAc2 binding to calnexin, a chaperone protein involved in CFTR-ΔF 508 retention. A convergent route to its methyl glycoside, the title tetrasaccharide, was developed. Th

Efficient installation of β-mannosides using a dehydrative coupling strategy

(Chemical Equation Presented) A new coupling procedure for the construction of the challenging β-mannosidic bond is described. Dehydrative mannosylation using 4,6-O-benzylidene mannopyranoses allows for the formation of β-mannosides in excellent yield. Th