2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Base Information

• Chemical Name: 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one
• CAS No.: 178944-65-5
• Molecular Formula: C₂₈H₂₈N₂O₄S
• Molecular Weight: 488.607
• Mol file: 178944-65-5.mol

Synonyms:2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Chemical Property of 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

There total 6 articles about 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane (178944-68-8) → 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one (178944-65-5)

Guidance literature:

With water; bis-[(trifluoroacetoxy)iodo]benzene; In acetonitrile; for 2h; Ambient temperature;

DOI:10.1016/0040-4020(96)00399-7

Reference yield: 19.0%

7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (178944-67-7) → 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one (178944-65-5)

Guidance literature:

With hydrogenchloride; In methanol; for 12h; Heating;

DOI:10.1016/0040-4020(96)00399-7

Reference yield:

2-<1-(phenylsulfonyl)-2-indolyl>-4-piperidone ethylene acetal (142207-40-7) → 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one (178944-65-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / K₂CO₃ / acetone / 48 h / Heating

2: 40 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / 40 °C

3: 82 percent / NaH / tetrahydrofuran; diethyl ether / Ambient temperature

4: 96 percent / H₂O, (CF₃COO)2IC₆H₅ / acetonitrile / 2 h / Ambient temperature

With boron trifluoride diethyl etherate; water; sodium hydride; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; acetonitrile;

DOI:10.1016/0040-4020(96)00399-7

upstream raw materials:

7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

benzyl iodoethyl ether

2-<1-(phenylsulfonyl)-2-indolyl>-4-piperidone ethylene acetal

Downstream raw materials:

2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one oxime

2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one oxime

C₃₅H₃₅N₃O₆S₂

C₃₅H₃₅N₃O₆S₂