2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Base Information

Chemical Name:2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one
CAS No.:178944-65-5
Molecular Formula:C₂₈H₂₈N₂O₄S
Molecular Weight:488.607
Hs Code.:

Synonyms:2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

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Chemical Property of 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

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Technology Process of 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

There total 6 articles about 2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 178944-68-8
8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

: 178944-65-5
2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Guidance literature:: With water; bis-[(trifluoroacetoxy)iodo]benzene; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1016/0040-4020(96)00399-7

Reference yield: 19.0%

: 178944-67-7
7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

: 178944-65-5
2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Guidance literature:: With hydrogenchloride; In methanol; for 12h; Heating;
DOI:10.1016/0040-4020(96)00399-7

Reference yield:

: 142207-40-7
2-<1-(phenylsulfonyl)-2-indolyl>-4-piperidone ethylene acetal

: 178944-65-5
2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / K₂CO₃ / acetone / 48 h / Heating

2: 40 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / 40 °C

3: 82 percent / NaH / tetrahydrofuran; diethyl ether / Ambient temperature

4: 96 percent / H₂O, (CF₃COO)2IC₆H₅ / acetonitrile / 2 h / Ambient temperature

With boron trifluoride diethyl etherate; water; sodium hydride; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; acetonitrile;
DOI:10.1016/0040-4020(96)00399-7